Anticholinergic exposure and its association with dementia/Alzheimer’s disease and mortality in older adults

By: Insiya B. Poonawalla, Yihua Xu, Rainelle Gaddy, Alex James, Matt Ruble, Salina Burns, Suzanne W. Dixon, Brandon T. Suehs

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This retrospective cohort study using real-world claims to describe the demographics and clinical characteristics of a large population of Medicare Advantage prescription drug (MAPD) confirmed the association between anticholinergic (ACH) medication exposure and increased risk of dementia/Alzheimer’s disease diagnosis and mortality. Reducing ACH exposure may potentially minimize long-term adverse effects in older adults. Results suggest populations which may benefit from targeted interventions to reduce ACH polypharmacy.

Read article: BMC Geriatrics